Effect and mechanism of immune surveillance activated by autotransfusion on reducing liver cancer metastasis based on HLA-DQB1/PDCD1

Introduction Liver cancer is a common tumor of digestive system. Hepatectomy sometimes results in massive hemorrhage, and intraoperative autotransfusion often required. Material methods Methods: In this basic research, the liver rat model was established, visible tissue surgically removed, blood mice recovered. Results The showed that group had highest recurrence metastasis cancer, lowest group. Flow cytometry number HLA-DQB1 positive cells, content CD4+CD25+T proliferation CD4+T cells were most group, followed by least auto+HLA-DQB1 which no difference from control Immunohistochemistry western blot analysis expression PDCD1 protein significant auto-HLA-DQB1, Conclusions It elucidates molecular mechanism will activate up-regulated signal molecule HLA-DQB1, enhance immune surveillance reduce on surface inhibit metastasis.Autotransfusion activated signaling enhanced reduced cancer.